Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation

Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the CNS that causes disability in young adults as a result of the irreversible accumulation of neurological deficits. Although there are potent disease-modifying agents for its initial relapsing-remitting phase, these the...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rothhammer, Veit, Kenison, Jessica E., Tjon, Emily, Takenaka, Maisa C., de Lima, Kalil Alves, Borucki, Davis M., Chao, Chun-Cheih, Wilz, Annabel, Blain, Manon, Healy, Luke, Antel, Jack, Quintana, Francisco J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338419/
https://ncbi.nlm.nih.gov/pubmed/28167760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615413114
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