Metabolic control of type 1 regulatory (Tr1) cell differentiation by AHR and HIF1-α

Our understanding of the pathways that regulate lymphocyte metabolism, as well as the effects of metabolism and its products on the immune response, is still limited. We report that a metabolic program controlled by the transcription factors hypoxia inducible factor-1α (HIF1-α) and aryl hydrocarbon...

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Publicado no:Nat Med
Main Authors: Mascanfroni, Ivan D., Takenaka, Maisa C., Yeste, Ada, Patel, Bonny, Wu, Yan, Kenison, Jessica E., Siddiqui, Shafiuddin, Basso, Alexandre S., Otterbein, Leo E., Pardoll, Drew M., Pan, Fan, Priel, Avner, Clish, Clary B., Robson, Simon C., Quintana, Francisco J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476246/
https://ncbi.nlm.nih.gov/pubmed/26005855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3868
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