The Novel Antitubulin Agent TR-764 Strongly Reduces Tumor Vasculature and Inhibits HIF-1α Activation

Tubulin binding agents (TBAs) are commonly used in cancer therapy as antimitotics. It has been described that TBAs, like combretastatin A-4 (CA-4), present also antivascular activity and among its derivatives we identified TR-764 as a new inhibitor of tubulin polymerization, based on the 2-(alkoxyca...

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Publicado no:Sci Rep
Main Authors: Porcù, Elena, Persano, Luca, Ronca, Roberto, Mitola, Stefania, Bortolozzi, Roberta, Romagnoli, Romeo, Oliva, Paola, Basso, Giuseppe, Viola, Giampietro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904223/
https://ncbi.nlm.nih.gov/pubmed/27292568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27886
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