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Convergent Synthesis and Biological Evaluation of 2-Amino-4-(3′,4′,5′-trimethoxyphenyl)-5-aryl Thiazoles as Microtubule Targeting Agents

[Image: see text] Combretastatin A-4, a potent tubulin polymerization inhibitor, caused us to synthesize a novel series of 2-amino-4-(3′,4′,5′-trimethoxyphenyl)-5-aryl thiazoles with the goal of evaluating the effects of substituents on the phenyl at the 5-position of the thiazole skeleton on biolog...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Romagnoli, Romeo, Baraldi, Pier Giovanni, Brancale, Andrea, Ricci, Antonio, Hamel, Ernest, Bortolozzi, Roberta, Basso, Giuseppe, Viola, Giampietro
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150540/
https://ncbi.nlm.nih.gov/pubmed/21663319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200392p
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