Metabolic control of astrocyte pathogenic activity via cPLA2-MAVS

Metabolism has been shown to control peripheral immunity, but little is known about its role in central nervous system (CNS) inflammation. Through a combination of proteomic, metabolomic, transcriptomic and perturbation studies, we found that sphingolipid metabolism in astrocytes triggers the intera...

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Publicado no:Cell
Main Authors: Chao, Chun-Cheih, Gutiérrez-Vázquez, Cristina, Rothhammer, Veit, Mayo, Lior, Wheeler, Michael A., Tjon, Emily C., Zandee, Stephanie E. J., Blain, Manon, De Lima, Kalil Alves, Takenaka, Maisa C., Avila-Pacheco, Julian, Hewson, Patrick, Liu, Lei, Sanmarco, Liliana M., Borucki, Davis M., Lipof, Gabriel Z., Trauger, Sunia A., Clish, Clary B., Antel, Jack P., Prat, Alexandre, Quintana, Francisco J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936326/
https://ncbi.nlm.nih.gov/pubmed/31813625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.11.016
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