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Cryo-EM reveals the steric zipper structure of a light chain-derived amyloid fibril
Amyloid fibrils are proteinaceous aggregates associated with diseases in humans and animals. The fibrils are defined by intermolecular interactions between the fibril-forming polypeptide chains, but it has so far remained difficult to reveal the assembly of the peptide subunits in a full-scale fibri...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4896715/ https://ncbi.nlm.nih.gov/pubmed/27185936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522282113 |
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