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Cryo-EM reveals the steric zipper structure of a light chain-derived amyloid fibril

Amyloid fibrils are proteinaceous aggregates associated with diseases in humans and animals. The fibrils are defined by intermolecular interactions between the fibril-forming polypeptide chains, but it has so far remained difficult to reveal the assembly of the peptide subunits in a full-scale fibri...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Schmidt, Andreas, Annamalai, Karthikeyan, Schmidt, Matthias, Grigorieff, Nikolaus, Fändrich, Marcus
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896715/
https://ncbi.nlm.nih.gov/pubmed/27185936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522282113
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