Detecting DNA Double-Stranded Breaks in Mammalian Genomes by Linear Amplification-mediated High-Throughput Genome-wide Translocation Sequencing (LAM-HTGTS)

Unbiased, high-throughput assays to detect and quantify DNA double-stranded breaks (DSBs) genome-wide in mammalian cells will facilitate basic studies of mechanisms that generate and repair endogenous DSBs. They will also enable more applied studies, such as evaluating on- and off-target activities...

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Veröffentlicht in:Nat Protoc
Hauptverfasser: Hu, Jiazhi, Meyers, Robin M., Dong, Junchao, Panchakshari, Rohit A., Alt, Frederick W., Frock, Richard L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4895203/
https://ncbi.nlm.nih.gov/pubmed/27031497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2016.043
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