Ex vivo mammalian prions are formed of paired double helical prion protein fibrils

Mammalian prions are hypothesized to be fibrillar or amyloid forms of prion protein (PrP), but structures observed to date have not been definitively correlated with infectivity and the three-dimensional structure of infectious prions has remained obscure. Recently, we developed novel methods to obt...

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Dades bibliogràfiques
Publicat a:Open Biol
Autors principals: Terry, Cassandra, Wenborn, Adam, Gros, Nathalie, Sells, Jessica, Joiner, Susan, Hosszu, Laszlo L. P., Tattum, M. Howard, Panico, Silvia, Clare, Daniel K., Collinge, John, Saibil, Helen R., Wadsworth, Jonathan D. F.
Format: Artigo
Idioma:Inglês
Publicat: The Royal Society 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4892434/
https://ncbi.nlm.nih.gov/pubmed/27249641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160035
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