Ex vivo mammalian prions are formed of paired double helical prion protein fibrils

Mammalian prions are hypothesized to be fibrillar or amyloid forms of prion protein (PrP), but structures observed to date have not been definitively correlated with infectivity and the three-dimensional structure of infectious prions has remained obscure. Recently, we developed novel methods to obt...

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Detalhes bibliográficos
Publicado no:Open Biol
Main Authors: Terry, Cassandra, Wenborn, Adam, Gros, Nathalie, Sells, Jessica, Joiner, Susan, Hosszu, Laszlo L. P., Tattum, M. Howard, Panico, Silvia, Clare, Daniel K., Collinge, John, Saibil, Helen R., Wadsworth, Jonathan D. F.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4892434/
https://ncbi.nlm.nih.gov/pubmed/27249641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160035
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