Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro

Seeded polymerisation of proteins forming amyloid fibres and their spread in tissues has been implicated in the pathogenesis of multiple neurodegenerative diseases: so called “prion-like” mechanisms. While ex vivo mammalian prions, composed of multichain assemblies of misfolded host-encoded prion pr...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Terry, Cassandra, Harniman, Robert L., Sells, Jessica, Wenborn, Adam, Joiner, Susan, Saibil, Helen R., Miles, Mervyn J., Collinge, John, Wadsworth, Jonathan D. F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344479/
https://ncbi.nlm.nih.gov/pubmed/30675000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36700-w
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