Ex vivo mammalian prions are formed of paired double helical prion protein fibrils

Mammalian prions are hypothesized to be fibrillar or amyloid forms of prion protein (PrP), but structures observed to date have not been definitively correlated with infectivity and the three-dimensional structure of infectious prions has remained obscure. Recently, we developed novel methods to obt...

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Bibliografiske detaljer
Udgivet i:Open Biol
Main Authors: Terry, Cassandra, Wenborn, Adam, Gros, Nathalie, Sells, Jessica, Joiner, Susan, Hosszu, Laszlo L. P., Tattum, M. Howard, Panico, Silvia, Clare, Daniel K., Collinge, John, Saibil, Helen R., Wadsworth, Jonathan D. F.
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4892434/
https://ncbi.nlm.nih.gov/pubmed/27249641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160035
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