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Discovery of prenylated flavonoids with dual activity against influenza virus and Streptococcus pneumoniae

Influenza virus neuraminidase (NA) is the primary target for influenza therapeutics. Severe complications are often related to secondary pneumonia caused by Streptococcus pneumoniae (pneumococci), which also express NAs. Recently, a NA-mediated lethal synergism between influenza A viruses and pneumo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Grienke, Ulrike, Richter, Martina, Walther, Elisabeth, Hoffmann, Anja, Kirchmair, Johannes, Makarov, Vadim, Nietzsche, Sandor, Schmidtke, Michaela, Rollinger, Judith M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891693/
https://ncbi.nlm.nih.gov/pubmed/27257160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27156
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