Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

During apoptosis, Bak and Bax are activated by BH3-only proteins binding to the α2–α5 hydrophobic groove; Bax is also activated via a rear pocket. Here we report that antibodies can directly activate Bak and mitochondrial Bax by binding to the α1–α2 loop. A monoclonal antibody (clone 7D10) binds clo...

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Udgivet i:Nat Commun
Main Authors: Iyer, Sweta, Anwari, Khatira, Alsop, Amber E., Yuen, Wai Shan, Huang, David C. S., Carroll, John, Smith, Nicholas A., Smith, Brian J., Dewson, Grant, Kluck, Ruth M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890306/
https://ncbi.nlm.nih.gov/pubmed/27217060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11734
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