Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations

A three-dimensional chromatin state underpins the structural and functional basis of the genome by bringing regulatory elements and genes into close spatial proximity to ensure proper, cell-type–specific gene expression profiles. Here, we performed Hi-C chromosome conformation capture sequencing to...

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Bibliografiske detaljer
Udgivet i:Genome Res
Main Authors: Taberlay, Phillippa C., Achinger-Kawecka, Joanna, Lun, Aaron T.L., Buske, Fabian A., Sabir, Kenneth, Gould, Cathryn M., Zotenko, Elena, Bert, Saul A., Giles, Katherine A., Bauer, Denis C., Smyth, Gordon K., Stirzaker, Clare, O'Donoghue, Sean I., Clark, Susan J.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889976/
https://ncbi.nlm.nih.gov/pubmed/27053337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.201517.115
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