Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations

A three-dimensional chromatin state underpins the structural and functional basis of the genome by bringing regulatory elements and genes into close spatial proximity to ensure proper, cell-type–specific gene expression profiles. Here, we performed Hi-C chromosome conformation capture sequencing to...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Genome Res
Autori principali: Taberlay, Phillippa C., Achinger-Kawecka, Joanna, Lun, Aaron T.L., Buske, Fabian A., Sabir, Kenneth, Gould, Cathryn M., Zotenko, Elena, Bert, Saul A., Giles, Katherine A., Bauer, Denis C., Smyth, Gordon K., Stirzaker, Clare, O'Donoghue, Sean I., Clark, Susan J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889976/
https://ncbi.nlm.nih.gov/pubmed/27053337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.201517.115
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi