Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains

The architectural protein CTCF is a mediator of chromatin conformation, but how CTCF binding to DNA is orchestrated to maintain long-range gene expression is poorly understood. Here we perform RNAi knockdown to reduce CTCF levels and reveal a shared subset of CTCF-bound sites are robustly resistant...

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Udgivet i:Nat Commun
Main Authors: Khoury, Amanda, Achinger-Kawecka, Joanna, Bert, Saul A., Smith, Grady C., French, Hugh J., Luu, Phuc-Loi, Peters, Timothy J., Du, Qian, Parry, Aled J., Valdes-Mora, Fatima, Taberlay, Phillippa C., Stirzaker, Clare, Statham, Aaron L., Clark, Susan J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946690/
https://ncbi.nlm.nih.gov/pubmed/31911579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13753-7
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