Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations

A three-dimensional chromatin state underpins the structural and functional basis of the genome by bringing regulatory elements and genes into close spatial proximity to ensure proper, cell-type–specific gene expression profiles. Here, we performed Hi-C chromosome conformation capture sequencing to...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Taberlay, Phillippa C., Achinger-Kawecka, Joanna, Lun, Aaron T.L., Buske, Fabian A., Sabir, Kenneth, Gould, Cathryn M., Zotenko, Elena, Bert, Saul A., Giles, Katherine A., Bauer, Denis C., Smyth, Gordon K., Stirzaker, Clare, O'Donoghue, Sean I., Clark, Susan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889976/
https://ncbi.nlm.nih.gov/pubmed/27053337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.201517.115
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