Mitochondria-translocated phosphoglycerate kinase 1 functions as a protein kinase to coordinate glycolysis and TCA cycle in tumorigenesis

It is unclear how the Warburg effect that exemplifies enhanced glycolysis in the cytosol is coordinated with suppressed mitochondrial pyruvate metabolism. We demonstrate here that hypoxia, EGFR activation, and expression of K-Ras G12V and B-Raf V600E induce mitochondrial translocation of phosphoglyc...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cell
Egile Nagusiak: Li, Xinjian, Jiang, Yuhui, Meisenhelder, Jill, Yang, Weiwei, Hawke, David H., Zheng, Yanhua, Xia, Yan, Aldape, Kenneth, He, Jie, Hunter, Tony, Wang, Liwei, Lu, Zhimin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888784/
https://ncbi.nlm.nih.gov/pubmed/26942675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.02.009
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