PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

Tumor-specific pyruvate kinase M2 (PKM2) is essential for the Warburg effect. Besides its well-established role in aerobic glycolysis, PKM2 directly regulates gene transcription. However, the mechanism underlying this nonmetabolic function of PKM2 remains elusive. We show here that PKM2 directly bin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yang, Weiwei, Xia, Yan, Hawke, David, Li, Xinjian, Liang, Ji, Xing, Dongming, Aldape, Kenneth, Hunter, Tony, Yung, W K Alfred, Lu, Zhimin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431020/
https://ncbi.nlm.nih.gov/pubmed/22901803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.07.018
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