PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

Tumor-specific pyruvate kinase M2 (PKM2) is essential for the Warburg effect. Besides its well-established role in aerobic glycolysis, PKM2 directly regulates gene transcription. However, the mechanism underlying this nonmetabolic function of PKM2 remains elusive. We show here that PKM2 directly bin...

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Autores principales: Yang, Weiwei, Xia, Yan, Hawke, David, Li, Xinjian, Liang, Ji, Xing, Dongming, Aldape, Kenneth, Hunter, Tony, Yung, W K Alfred, Lu, Zhimin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431020/
https://ncbi.nlm.nih.gov/pubmed/22901803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.07.018
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