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PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

Tumor-specific pyruvate kinase M2 (PKM2) is essential for the Warburg effect. Besides its well-established role in aerobic glycolysis, PKM2 directly regulates gene transcription. However, the mechanism underlying this nonmetabolic function of PKM2 remains elusive. We show here that PKM2 directly bin...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Yang, Weiwei, Xia, Yan, Hawke, David, Li, Xinjian, Liang, Ji, Xing, Dongming, Aldape, Kenneth, Hunter, Tony, Yung, W K Alfred, Lu, Zhimin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2012
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431020/
https://ncbi.nlm.nih.gov/pubmed/22901803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.07.018
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