PKM2 regulates chromosome segregation and mitosis progression of tumor cells

Tumor-specific pyruvate kinase M2 (PKM2) is instrumental in both aerobic glycolysis and gene transcription. PKM2 regulates G1-S phase transition by controlling cyclin D1 expression. However, it is not known whether PKM2 directly controls cell cycle progression. We show here that PKM2, but not PKM1,...

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Библиографические подробности
Главные авторы: Jiang, Yuhui, Li, Xinjian, Yang, Weiwei, Hawke, David H., Zheng, Yanhua, Xia, Yan, Aldape, Kenneth, Wei, Chongyang, Guo, Fang, Chen, Yan, Lu, Zhimin
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3955203/
https://ncbi.nlm.nih.gov/pubmed/24316223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.11.001
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