Mitochondria-translocated phosphoglycerate kinase 1 functions as a protein kinase to coordinate glycolysis and TCA cycle in tumorigenesis

It is unclear how the Warburg effect that exemplifies enhanced glycolysis in the cytosol is coordinated with suppressed mitochondrial pyruvate metabolism. We demonstrate here that hypoxia, EGFR activation, and expression of K-Ras G12V and B-Raf V600E induce mitochondrial translocation of phosphoglyc...

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Publicat a:Mol Cell
Autors principals: Li, Xinjian, Jiang, Yuhui, Meisenhelder, Jill, Yang, Weiwei, Hawke, David H., Zheng, Yanhua, Xia, Yan, Aldape, Kenneth, He, Jie, Hunter, Tony, Wang, Liwei, Lu, Zhimin
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888784/
https://ncbi.nlm.nih.gov/pubmed/26942675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.02.009
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