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PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis
Many types of human tumour cells overexpress the dual-specificity phosphatase Cdc25A. Cdc25A dephosphorylates cyclin-dependent kinase and regulates the cell cycle, but other substrates of Cdc25A and their relevant cellular functions have yet to be identified. We demonstrate here that EGFR activation...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4976202/ https://ncbi.nlm.nih.gov/pubmed/27485204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12431 |
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