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Nuclear PKM2 regulates the Warburg effect
Pyruvate kinase is a rate-limiting glycolytic enzyme. The PKM1 and PKM2 isoforms result from mutually exclusive alternative splicing of the PKM pre-mRNA. PKM2 rather than PKM1 regulates the Warburg effect and tumorigenesis by poorly understood mechanisms. Emerging evidence has revealed that ERK1/2 p...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Landes Bioscience
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3865010/ https://ncbi.nlm.nih.gov/pubmed/24013426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26182 |
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