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Nuclear PKM2 regulates the Warburg effect

Pyruvate kinase is a rate-limiting glycolytic enzyme. The PKM1 and PKM2 isoforms result from mutually exclusive alternative splicing of the PKM pre-mRNA. PKM2 rather than PKM1 regulates the Warburg effect and tumorigenesis by poorly understood mechanisms. Emerging evidence has revealed that ERK1/2 p...

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Bibliographic Details
Main Authors: Yang, Weiwei, Lu, Zhimin
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865010/
https://ncbi.nlm.nih.gov/pubmed/24013426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26182
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