Phosphoglycerate kinase 1 phosphorylates Beclin1 to induce autophagy

Autophagy is crucial for maintaining cell homeostasis. However, the precise mechanism underlying autophagy initiation remains to be defined. Here, we demonstrate that glutamine deprivation and hypoxia result in inhibition of mTOR-mediated acetyl-transferase ARD1 S228 phosphorylation, leading to ARD1...

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Pubblicato in:Mol Cell
Autori principali: Qian, Xu, Li, Xinjian, Cai, Qingsong, Zhang, Chuanbao, Jiang, Yuhui, Lee, Jong-Ho, Hawke, David, Wang, Yugang, Xia, Yan, Zheng, Yanhua, Jiang, Bing-Hua, Liu, David X., Jiang, Tao, Lu, Zhimin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389741/
https://ncbi.nlm.nih.gov/pubmed/28238651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.01.027
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