Phosphoglycerate kinase 1 phosphorylates Beclin1 to induce autophagy

Autophagy is crucial for maintaining cell homeostasis. However, the precise mechanism underlying autophagy initiation remains to be defined. Here, we demonstrate that glutamine deprivation and hypoxia result in inhibition of mTOR-mediated acetyl-transferase ARD1 S228 phosphorylation, leading to ARD1...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Cell
Main Authors: Qian, Xu, Li, Xinjian, Cai, Qingsong, Zhang, Chuanbao, Jiang, Yuhui, Lee, Jong-Ho, Hawke, David, Wang, Yugang, Xia, Yan, Zheng, Yanhua, Jiang, Bing-Hua, Liu, David X., Jiang, Tao, Lu, Zhimin
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389741/
https://ncbi.nlm.nih.gov/pubmed/28238651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.01.027
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