Phosphoglycerate kinase 1 phosphorylates Beclin1 to induce autophagy

Autophagy is crucial for maintaining cell homeostasis. However, the precise mechanism underlying autophagy initiation remains to be defined. Here, we demonstrate that glutamine deprivation and hypoxia result in inhibition of mTOR-mediated acetyl-transferase ARD1 S228 phosphorylation, leading to ARD1...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell
Asıl Yazarlar: Qian, Xu, Li, Xinjian, Cai, Qingsong, Zhang, Chuanbao, Jiang, Yuhui, Lee, Jong-Ho, Hawke, David, Wang, Yugang, Xia, Yan, Zheng, Yanhua, Jiang, Bing-Hua, Liu, David X., Jiang, Tao, Lu, Zhimin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389741/
https://ncbi.nlm.nih.gov/pubmed/28238651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.01.027
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