An unbiased metric of antiproliferative drug effect in vitro

In vitro cell proliferation assays are widely used in pharmacology, molecular biology, and drug discovery. Using theoretical modeling and experimentation, we show that current antiproliferative drug effect metrics suffer from time-dependent bias, leading to inaccurate assessments of parameters such...

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Detaylı Bibliyografya
Yayımlandı:Nat Methods
Asıl Yazarlar: Harris, Leonard A., Frick, Peter L., Garbett, Shawn P., Hardeman, Keisha N., Paudel, B. Bishal, Lopez, Carlos F., Quaranta, Vito, Tyson, Darren R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887341/
https://ncbi.nlm.nih.gov/pubmed/27135974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3852
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