IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

Oncogenic mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in several types of cancer, but the metabolic consequences of these genetic changes are not fully understood. In this study, we performed (13)C metabolic flux analysis on a panel of isogenic cell lines containing heterozygous IDH...

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Udgivet i:Cancer Res
Main Authors: Grassian, Alexandra R., Parker, Seth J., Davidson, Shawn M., Divakarun, Ajit S., Green, Courtney R., Zhang, Xiamei, Slocum, Kelly L., Pu, Minying, Lin, Fallon, Vickers, Chad, Joud-Caldwell, Carol, Chung, Franklin, Yin, Hong, Handly, Erika D., Straub, Christopher, Growney, Joseph D., Vander Heiden, Matthew G., Murphy, Anne N., Pagliarini, Raymond, Metallo, Christian M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885639/
https://ncbi.nlm.nih.gov/pubmed/24755473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0772-T
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