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Metabolic consequences of oncogenic IDH mutations
Specific point mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) occur in a variety of cancers, including acute myeloid leukemia (AML), low-grade gliomas, and chondrosarcomas. These mutations inactivate wild-type enzymatic activity and convey neomorphic function to produce D-2-hydroxyglu...
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| 發表在: | Pharmacol Ther |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4489982/ https://ncbi.nlm.nih.gov/pubmed/25956465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2015.05.003 |
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