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IDH1 mutation induces reprogramming of pyruvate metabolism

Mutant isocitrate dehydrogenase 1 (IDH1) catalyzes the production of 2-hydroxyglutarate but also elicits additional metabolic changes. Levels of both glutamate and pyruvate dehydrogenase (PDH) activity have been shown to be affected in U87 glioblastoma cells or normal human astrocyte (NHA) cells exp...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Izquierdo-Garcia, Jose L., Viswanath, Pavithra, Eriksson, Pia, Cai, Larry, Radoul, Marina, Chaumeil, Myriam M., Blough, M., Luchman, H. Artee, Weiss, Samuel, Cairncross, J. Gregory, Phillips, Joanna J., Pieper, Russell O., Ronen, Sabrina M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526330/
https://ncbi.nlm.nih.gov/pubmed/26045167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0840
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