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Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors

Breast cancer is one of the leading causes of death worldwide, and therefore, new and improved approaches for the treatment of breast cancer are desperately needed. CtIP (RBBP8) is a multifunctional protein that is involved in various cellular functions, including transcription, DNA replication, DNA...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Junhui, Ding, Qianshan, Fujimori, Hiroaki, Motegi, Akira, Miki, Yoshio, Masutani, Mitsuko
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884948/
https://ncbi.nlm.nih.gov/pubmed/26713604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6715
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