SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development

Skp1‐Cul1‐F‐box protein (SCF) ubiquitin ligases direct cell survival decisions by controlling protein ubiquitylation and degradation. Sufu (Suppressor of fused) is a central regulator of Hh (Hedgehog) signaling and acts as a tumor suppressor by maintaining the Gli (Glioma‐associated oncogene homolog...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Raducu, Madalina, Fung, Ella, Serres, Sébastien, Infante, Paola, Barberis, Alessandro, Fischer, Roman, Bristow, Claire, Thézénas, Marie‐Laëtitia, Finta, Csaba, Christianson, John C, Buffa, Francesca M, Kessler, Benedikt M, Sibson, Nicola R, Di Marcotullio, Lucia, Toftgård, Rune, D'Angiolella, Vincenzo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884786/
https://ncbi.nlm.nih.gov/pubmed/27234298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593374
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