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Peptides Comprised of Alternating L- and D- Amino Acids Inhibit Amyloidogenesis in Three Distinct Amyloid Systems Independent of Sequence

There is now substantial evidence that soluble oligomers are primary toxic agents in amyloid diseases. Development of an antibody recognizing the toxic soluble oligomeric forms of different and unrelated amyloid species suggests a common conformational intermediate during amyloidogenesis. We previou...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Kellock, Jackson, Hopping, Gene, Caughey, Byron, Daggett, Valerie
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884539/
https://ncbi.nlm.nih.gov/pubmed/27012425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.03.013
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