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Chemical and Physical Variability in Structural Isomers of an L/D α-Sheet Peptide Designed To Inhibit Amyloidogenesis

There has been much interest in synthetic peptides as inhibitors of aggregation associated with amyloid diseases. Of particular interest are compounds that target the cytotoxic soluble oligomers preceding the formation of mature, nontoxic fibrils. This study explores physical and chemical difference...

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Vydáno v:Biochemistry
Hlavní autoři: Maris, Nathan L., Shea, Dylan, Bleem, Alissa, Bryers, James D., Daggett, Valerie
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801053/
https://ncbi.nlm.nih.gov/pubmed/29202245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00345
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