Designed α-sheet peptides inhibit amyloid formation by targeting toxic oligomers

Previous studies suggest that the toxic soluble-oligomeric form of different amyloid proteins share a common backbone conformation, but the amorphous nature of this oligomer prevents its structural characterization by experiment. Based on molecular dynamics simulations we proposed that toxic interme...

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Detalhes bibliográficos
Main Authors: Hopping, Gene, Kellock, Jackson, Barnwal, Ravi Pratap, Law, Peter, Bryers, James, Varani, Gabriele, Caughey, Byron, Daggett, Valerie
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Biophysics and Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091096/
https://ncbi.nlm.nih.gov/pubmed/25027691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01681
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