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Designed Trpzip-3 β-Hairpin Inhibits Amyloid Formation in Two Different Amyloid Systems
[Image: see text] The trpzip peptides are small, monomeric, and extremely stable β-hairpins that have become valuable tools for studying protein folding. Here, we show that trpzip-3 inhibits aggregation in two very different amyloid systems: transthyretin and Aβ(1–42). Interestingly, Trp → Leu mutat...
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| Główni autorzy: | , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Chemical Society
2013
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| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027462/ https://ncbi.nlm.nih.gov/pubmed/24900756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300478w |
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