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Stabilization of a β-hairpin in monomeric Alzheimer's amyloid-β peptide inhibits amyloid formation

According to the amyloid hypothesis, the pathogenesis of Alzheimer's disease is triggered by the oligomerization and aggregation of the amyloid-β (Aβ) peptide into protein plaques. Formation of the potentially toxic oligomeric and fibrillar Aβ assemblies is accompanied by a conformational chang...

詳細記述

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書誌詳細
主要な著者: Hoyer, Wolfgang, Grönwall, Caroline, Jonsson, Andreas, Ståhl, Stefan, Härd, Torleif
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278213/
https://ncbi.nlm.nih.gov/pubmed/18375754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711731105
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