SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair

Sirtuins, a family of protein deacetylases, promote cellular homeostasis by mediating communication between cells and environment. The enzymatic activity of the mammalian sirtuin SIRT7 targets acetylated lysine in the N‐terminal tail of histone H3 (H3K18Ac), thus modulating chromatin structure and t...

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Dettagli Bibliografici
Pubblicato in:EMBO J
Autori principali: Vazquez, Berta N, Thackray, Joshua K, Simonet, Nicolas G, Kane‐Goldsmith, Noriko, Martinez‐Redondo, Paloma, Nguyen, Trang, Bunting, Samuel, Vaquero, Alejandro, Tischfield, Jay A, Serrano, Lourdes
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884211/
https://ncbi.nlm.nih.gov/pubmed/27225932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593499
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