SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair

Sirtuins, a family of protein deacetylases, promote cellular homeostasis by mediating communication between cells and environment. The enzymatic activity of the mammalian sirtuin SIRT7 targets acetylated lysine in the N‐terminal tail of histone H3 (H3K18Ac), thus modulating chromatin structure and t...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Vazquez, Berta N, Thackray, Joshua K, Simonet, Nicolas G, Kane‐Goldsmith, Noriko, Martinez‐Redondo, Paloma, Nguyen, Trang, Bunting, Samuel, Vaquero, Alejandro, Tischfield, Jay A, Serrano, Lourdes
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884211/
https://ncbi.nlm.nih.gov/pubmed/27225932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593499
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