The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation

The establishment of the epigenetic mark H4K20me1 (monomethylation of H4K20) by PR-Set7 during G(2)/M directly impacts S-phase progression and genome stability. However, the mechanisms involved in the regulation of this event are not well understood. Here we show that SirT2 regulates H4K20me1 deposi...

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Detalhes bibliográficos
Principais autores: Serrano, Lourdes, Martínez-Redondo, Paloma, Marazuela-Duque, Anna, Vazquez, Berta N., Dooley, Scott J., Voigt, Philipp, Beck, David B., Kane-Goldsmith, Noriko, Tong, Qiang, Rabanal, Rosa M., Fondevila, Dolors, Muñoz, Purificación, Krüger, Marcus, Tischfield, Jay A., Vaquero, Alejandro
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613611/
https://ncbi.nlm.nih.gov/pubmed/23468428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.211342.112
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