SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1

Sirtuins are key players of metabolic stress response. Originally described as deacetylases, some sirtuins also exhibit poorly understood mono–adenosine 5′-diphosphate (ADP)–ribosyltransferase (mADPRT) activity. We report that the deacetylase SirT7 is a dual sirtuin, as it also features auto-mADPRT...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Simonet, Nicolás G., Thackray, Joshua K., Vazquez, Berta N., Ianni, Alessandro, Espinosa-Alcantud, Maria, Morales-Sanfrutos, Julia, Hurtado-Bagès, Sarah, Sabidó, Eduard, Buschbeck, Marcus, Tischfield, Jay, De La Torre, Carolina, Esteller, Manel, Braun, Thomas, Olivella, Mireia, Serrano, Lourdes, Vaquero, Alejandro
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7439345/
https://ncbi.nlm.nih.gov/pubmed/32832656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz2590
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