Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms

Topoisomerase 1 (TOP1) inhibitors, including camptothecin and topotecan, covalently trap TOP1 on DNA, creating cleavage complexes (cc’s) that must be resolved before gene transcription and DNA replication can proceed. We previously found that topotecan reduces the expression of long (>100 kb) gen...

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Publicat a:PLoS One
Autors principals: Mabb, Angela M., Simon, Jeremy M., King, Ian F., Lee, Hyeong-Min, An, Lin-Kun, Philpot, Benjamin D., Zylka, Mark J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4883752/
https://ncbi.nlm.nih.gov/pubmed/27231886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156439
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