Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

Angelman syndrome is a severe neurodevelopmental disorder caused by deletion or mutation of the maternal allele of the ubiquitin protein ligase E3A (Ube3a)(1–3). In neurons, the paternal allele of Ube3a is intact but epigenetically silenced(4–6), raising the possibility that Angelman syndrome could...

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Détails bibliographiques
Auteurs principaux: Huang, Hsien-Sung, Allen, John A., Mabb, Angela M., King, Ian F., Miriyala, JayaLakshmi, Taylor-Blake, Bonnie, Sciaky, Noah, Dutton, J. Walter, Lee, Hyeong-Min, Chen, Xin, Jin, Jian, Bridges, Arlene S., Zylka, Mark J., Roth, Bryan L., Philpot, Benjamin D.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257422/
https://ncbi.nlm.nih.gov/pubmed/22190039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10726
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