Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

Angelman syndrome is a severe neurodevelopmental disorder caused by deletion or mutation of the maternal allele of the ubiquitin protein ligase E3A (Ube3a)(1–3). In neurons, the paternal allele of Ube3a is intact but epigenetically silenced(4–6), raising the possibility that Angelman syndrome could...

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Bibliografiske detaljer
Main Authors: Huang, Hsien-Sung, Allen, John A., Mabb, Angela M., King, Ian F., Miriyala, JayaLakshmi, Taylor-Blake, Bonnie, Sciaky, Noah, Dutton, J. Walter, Lee, Hyeong-Min, Chen, Xin, Jin, Jian, Bridges, Arlene S., Zylka, Mark J., Roth, Bryan L., Philpot, Benjamin D.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257422/
https://ncbi.nlm.nih.gov/pubmed/22190039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10726
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