Topoisomerases facilitate transcription of long genes linked to autism

Topoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is unknown. Here we found that topotecan, a Topoisomerase 1 (TOP1) inhibitor, dose-dependen...

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Detalhes bibliográficos
Main Authors: King, Ian F., Yandava, Chandri N., Mabb, Angela M., Hsiao, Jack S., Huang, Hsien-Sung, Pearson, Brandon L., Calabrese, J. Mauro, Starmer, Joshua, Parker, Joel S., Magnuson, Terry, Chamberlain, Stormy J., Philpot, Benjamin D., Zylka, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767287/
https://ncbi.nlm.nih.gov/pubmed/23995680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12504
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