Topoisomerases facilitate transcription of long genes linked to autism

Topoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is unknown. Here we found that topotecan, a Topoisomerase 1 (TOP1) inhibitor, dose-dependen...

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Hlavní autoři: King, Ian F., Yandava, Chandri N., Mabb, Angela M., Hsiao, Jack S., Huang, Hsien-Sung, Pearson, Brandon L., Calabrese, J. Mauro, Starmer, Joshua, Parker, Joel S., Magnuson, Terry, Chamberlain, Stormy J., Philpot, Benjamin D., Zylka, Mark J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767287/
https://ncbi.nlm.nih.gov/pubmed/23995680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12504
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