Topoisomerase 1 inhibition reversibly impairs synaptic function

Topotecan is a topoisomerase 1 (TOP1) inhibitor that is used to treat various forms of cancer. We recently found that topotecan reduces the expression of multiple long genes, including many neuronal genes linked to synapses and autism. However, whether topotecan alters synaptic protein levels and sy...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Mabb, Angela M., Kullmann, Paul H. M., Twomey, Margaret A., Miriyala, Jayalakshmi, Philpot, Benjamin D., Zylka, Mark J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260568/
https://ncbi.nlm.nih.gov/pubmed/25404338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413204111
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