Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

Angelman syndrome is a severe neurodevelopmental disorder caused by deletion or mutation of the maternal allele of the ubiquitin protein ligase E3A (Ube3a)(1–3). In neurons, the paternal allele of Ube3a is intact but epigenetically silenced(4–6), raising the possibility that Angelman syndrome could...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Huang, Hsien-Sung, Allen, John A., Mabb, Angela M., King, Ian F., Miriyala, JayaLakshmi, Taylor-Blake, Bonnie, Sciaky, Noah, Dutton, J. Walter, Lee, Hyeong-Min, Chen, Xin, Jin, Jian, Bridges, Arlene S., Zylka, Mark J., Roth, Bryan L., Philpot, Benjamin D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257422/
https://ncbi.nlm.nih.gov/pubmed/22190039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10726
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia