Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms

Topoisomerase 1 (TOP1) inhibitors, including camptothecin and topotecan, covalently trap TOP1 on DNA, creating cleavage complexes (cc’s) that must be resolved before gene transcription and DNA replication can proceed. We previously found that topotecan reduces the expression of long (>100 kb) gen...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Mabb, Angela M., Simon, Jeremy M., King, Ian F., Lee, Hyeong-Min, An, Lin-Kun, Philpot, Benjamin D., Zylka, Mark J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4883752/
https://ncbi.nlm.nih.gov/pubmed/27231886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156439
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