Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration

Topoisomerase 1 (TOP1) relieves torsional stress in DNA during transcription and facilitates the expression of long (>100 kb) genes, many of which are important for neuronal functions. To evaluate how loss of Top1 affected neurons in vivo, we conditionally deleted (cKO) Top1 in postmitotic excita...

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Publicado en:Nat Commun
Main Authors: Fragola, Giulia, Mabb, Angela M., Taylor-Blake, Bonnie, Niehaus, Jesse K., Chronister, William D., Mao, Hanqian, Simon, Jeremy M., Yuan, Hong, Li, Zibo, McConnell, Michael J., Zylka, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181881/
https://ncbi.nlm.nih.gov/pubmed/32327659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15794-9
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